
YM-155 hydrochloride
CAS No. 355406-09-6
YM-155 hydrochloride( YM155 hydrochloride | YM 155 hydrochloride )
Catalog No. M14215 CAS No. 355406-09-6
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 873 | Get Quote |
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50MG | 1782 | Get Quote |
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100MG | 2250 | Get Quote |
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200MG | Get Quote | Get Quote |
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Biological Information
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Product NameYM-155 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
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DescriptionA potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM; does not significantly inhibit SV40 promoter activity (>30 uM); suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins; induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).Blood Cancer Phase 1 Discontinued.
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In VitroSepantronium bromide (YM155; 30 μM) is not sensitive to survivn gene promoter-driven luciferase reporter activity. Sepantronium bromide shows significant supression on endogenous survivin expression in PC-3 and PPC-1 human HRPC cells with deficient p53 via transcriptional inhibition of the survivin gene promoter. Sepantronium bromide (100 nM) does not affect protein expression of c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin, and β-tubulin. Sepantronium bromide potently inhibits human cancer cell lines (mutated or truncated p53) such as PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5 and A375 with IC50s ranging from 2.3 to 11 nM, respectively. Sepantronium bromide (YM155) resultin in an increase in sensitivity of NSCLC cells to γ-radiation. Sepantronium bromide combined with γ-radiation increases both the number of apoptotic cells and the activity of caspase-3. In addition, Sepantronium bromide delays the repair of radiation-induced double-strand breaks in nuclear DNA.
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In VivoSepantronium bromide (YM155; 3 and 10 mg/kg) inhibits the tumor growth in PC-3 xenografts, without obvious body weight loss and blood cell count decrease. Sepantronium bromide is highly distributed to tumor tissue in vivo. Sepantronium bromide shows 80% TGI at a dose of 5 mg/kg in PC-3 orthotopic xenografts. Sepantronium bromide (YM155) in combination with γ-radiation shows potent antitumor activity against H460 or Calu6 xenografts in nude mice. In this orthotopic renal and metastatic lung tumors models, Sepantronium bromide (YM-155) and IL-2 additively decreases tumor weight, lung metastasis, and luciferin-stained tumor images.
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SynonymsYM155 hydrochloride | YM 155 hydrochloride
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PathwayApoptosis
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TargetIAP
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RecptorIAP
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number355406-09-6
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Formula Weight398.8429
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Molecular FormulaC20H19ClN4O3
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Cl-]
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Chemical Name1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(2-pyrazinylmethyl)-, chloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21.
2. Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.
3. Satoh T, et al. Clin Cancer Res. 2009 Jun 1;15(11):3872-80.
4. Iwasa T, et al. Br J Cancer. 2010 Jun 29;103(1):36-42.
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YM-155 hydrochloride
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.